Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.

@article{Dorner2009SelectiveEO,
  title={Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.},
  author={B. Dorner and M. Dorner and Xuefei Zhou and Corinna Opitz and A. Mora and Steffen G{\"u}ttler and A. Hutloff and H. Mages and Katja Ranke and M. Schaefer and R. Jack and V. Henn and R. Kroczek},
  journal={Immunity},
  year={2009},
  volume={31 5},
  pages={
          823-33
        }
}
The expression of the chemokine receptor XCR1 and the function of its ligand XCL1 (otherwise referred to as ATAC, lymphotactin, or SCM-1) remained elusive to date. In the present report we demonstrated that XCR1 is exclusively expressed on murine CD8(+) dendritic cells (DCs) and showed that XCL1 is a potent and highly specific chemoattractant for this DC subset. CD8(+) T cells abundantly secreted XCL1 8-36 hr after antigen recognition on CD8(+) DCs in vivo, in a period in which stable T cell-DC… Expand
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