Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.

@article{Zhang2005SelectiveEO,
  title={Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.},
  author={Dong Ji Zhang and Qi Wang and Jie Wei and Gyulnar Baimukanova and Frank Buchholz and Adrian Francis Stewart and Xiaohong Mao and Nigel Killeen},
  journal={Journal of immunology},
  year={2005},
  volume={174 11},
  pages={6725-31}
}
Transgenic mouse lines were generated that express the Cre recombinase under the control of the distal promoter of the mouse Lck gene. Cre recombination in four of these lines of transgenic mice was characterized at the single cell level using ROSA26-regulated loxP-Stop-loxP-betageo and loxP-Stop-loxP-YFP reporter mouse lines. Two of the lines showed T cell-restricted Cre recombination, whereas the other two also expressed Cre in B cells, NK cells, and monocytes. Cre recombination began at a… CONTINUE READING

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