Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.

@article{Yamanashi1989SelectiveEO,
  title={Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.},
  author={Yoshihide Yamanashi and Shigeo Mori and Minoru Yoshida and Tadamitsu Kishimoto and Kazushi Inoue and Toshiyuki Yamamoto and Kumao Toyoshima},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 17},
  pages={6538-42}
}
This paper reports the identification of the lyn gene product, a member of the src-related family of protein-tyrosine kinases, and its expression in hematopoietic cells. A lyn-specific sequence (Arg-25 to Ala-119 of the protein) was expressed in Escherichia coli as a fusion protein with beta-galactosidase. Antiserum raised against the fusion protein immunoprecipitated a 56-kDa protein from human B lymphocytes. Incubation of the immunoprecipitate with [gamma-32P]ATP resulted in the… CONTINUE READING

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