Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells.

@article{Matsumura2007SelectiveEO,
  title={Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells.},
  author={Yumiko Matsumura and Takashi Kobayashi and Kenji Ichiyama and Ryoko Yoshida and Masayuki Hashimoto and Tomohito Takimoto and Kentaro Tanaka and Takatoshi Chinen and Takashi Shichita and Tony Wyss-Coray and Katsuaki Sato and Akihiko Yoshimura},
  journal={Journal of immunology},
  year={2007},
  volume={179 4},
  pages={2170-9}
}
Dendritic cells (DCs) induce immunity and immunological tolerance as APCs. It has been shown that DCs secreting IL-10 induce IL-10(+) Tr1-type regulatory T (Treg) cells, whereas Foxp3-positive Treg cells are expanded from naive CD4(+) T cells by coculturing with mature DCs. However, the regulatory mechanism of expansion of Foxp3(+) Treg cells by DCs has not been clarified. In this study, we demonstrated that suppressors of cytokine signaling (SOCS)-3-deficient DCs have a strong potential as… CONTINUE READING

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