Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test.

@article{Clark2012SelectiveER,
  title={Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test.},
  author={Janet A. Clark and Sara Alves and Chrisana Gundlah and Benedita Rocha and Elizabeth T Birzin and S-J Cai and Ramon Flick and Edd Hayes and Kuo-Hao Ho and Sudha R. Warrier and Lee-yuh Pai and Joel B Yudkovitz and Rebecca Fleischer and Lawrence Colwell and Sheng Li and Hilary Wilkinson and Jon Schaeffer and Randall B. Wilkening and Erica Mattingly and Mandy Hammond and Susan P. Rohrer},
  journal={Neuropharmacology},
  year={2012},
  volume={63 6},
  pages={1051-63}
}
Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) which bind estradiol with similar affinities and mediate the effects of estrogen throughout the body. ERα plays a major role in reproductive physiology and behavior, and mediates classic estrogen signaling in such tissues as the uterus, mammary gland, and skeleton. ERβ, however, modulates estrogen signaling in the ovary, the immune system, prostate, gastrointestinal… CONTINUE READING
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