Selective esterase–ester pair for targeting small molecules with cellular specificity

@article{Tian2012SelectiveEP,
  title={Selective esterase–ester pair for targeting small molecules with cellular specificity},
  author={L. Tian and Y. Yang and Laura M. Wysocki and Alma Arnold and Amy Hu and B. Ravichandran and S. Sternson and L. Looger and L. Lavis},
  journal={Proceedings of the National Academy of Sciences},
  year={2012},
  volume={109},
  pages={4756 - 4761}
}
  • L. Tian, Y. Yang, +6 authors L. Lavis
  • Published 2012
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • Small molecules are important tools to measure and modulate intracellular signaling pathways. A longstanding limitation for using chemical compounds in complex tissues has been the inability to target bioactive small molecules to a specific cell class. Here, we describe a generalizable esterase–ester pair capable of targeted delivery of small molecules to living cells and tissue with cellular specificity. We used fluorogenic molecules to rapidly identify a small ester masking motif that is… CONTINUE READING

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