Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions.

@article{Jia1999SelectiveET,
  title={Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions.},
  author={G Q Jia and Jose Antonio Gonzalo and Andr{\'e}s Hidalgo and Desiree Wagner and Marta Cybulsky and Jos{\'e} Carlos Guti{\'e}rrez-Ramos},
  journal={International immunology},
  year={1999},
  volume={11 1},
  pages={1-10}
}
We have recently cloned eotaxin, a highly efficacious eosinophilic chemokine involved in the development of lung eosinophilia during allergic inflammatory reactions. To understand more precisely how eotaxin facilitates the specific migration of eosinophils, we have studied which adhesion receptors are essential for eotaxin action both in vivo and in vitro. Experiments using mice genetically deficient in adhesion receptors demonstrated that molecules previously reported to be involved in both… CONTINUE READING