Selective enhancement of an A type potassium current by dexamethasone in a corticotroph cell line.

@article{Pennington1994SelectiveEO,
  title={Selective enhancement of an A type potassium current by dexamethasone in a corticotroph cell line.},
  author={Angela Pennington and John B. Kelly and Ferenc A. Antoni},
  journal={Journal of neuroendocrinology},
  year={1994},
  volume={6 3},
  pages={305-15}
}
Perforated patch recording was used to examine the effect of the synthetic steroid dexamethasone on the whole cell potassium (K+) current, in the mouse corticotroph tumour cell line AtT20/D16-16. In 15 out of 52 control cells (29%) there was a rapidly-activating, rapidly-inactivating K+ current of the A type, the amplitude of which was strongly dependent on the holding potential in use prior to its activation by depolarising voltage pulses, and which was blocked by 1 mM 4-aminopyridine (4-AP, n… CONTINUE READING