• Corpus ID: 31096144

Selective enhancement of [3H]opiate agonist binding by divalent cations.

  title={Selective enhancement of [3H]opiate agonist binding by divalent cations.},
  author={Gavril W. Pasternak and Adele M. Snowman and Solomon H. Snyder},
  journal={Molecular pharmacology},
  volume={11 6},
Manganese ions enhance binding of the tritiated opiate agonists dihydromorphine and levorphanol 78% and 64%, respectively, while binding of the tritiated antagonists naloxone, levallorphan, and diprenorphine is unaffected. Magnesium and nickel ions also selectively enhance [3H]dihydromorphine binding with no effect on [3H]naloxone binding. By contrast, cupric and ferrous ions lower the binding of [3H]dihydromorphine far more than that of [3H]naloxone. Manganese ions also enhance the ability of… 

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