Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene.

@article{Kim1994SelectiveEB,
  title={Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene.},
  author={Jae Ho Kim and So Hee Kim and Stephen L Brown and Svend O. Freytag},
  journal={Cancer research},
  year={1994},
  volume={54 23},
  pages={6053-6}
}
The activation of antiviral drugs as a consequence of thymidine kinase expression has been shown in recent years to have potential as a treatment for malignant tumors. It was hypothesized that the property of the drugs that make them effective against viruses and proliferating cells, namely their ability to interfere with the integrity of the DNA, may be exploited to sensitize cells to radiation damage. The antiviral drug, BVdUrd, structurally a pyrimidine analogue, was found to enhance… CONTINUE READING