Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation.

Abstract

Mutations of FoxP3 result in the disturbance of FoxP3 expression and lack of functional CD4 CD25high regulatory T cells in humans, causing immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The only curative approach for IPEX syndrome, which is fatal within the first year of life in many cases, is allogeneic hematopoietic stem… (More)
DOI: 10.1182/blood-2009-02-206359

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