Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure.

@article{Mulder2000SelectiveEV,
  title={Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure.},
  author={Paul Mulder and Houssaine Boujedaini and Vincent Richard and Genevi{\`e}ve Anne Derumeaux and Jean Paul Henry and Sylvanie Renet and Jerry E. Wessale and Terry J. Opgenorth and Ch Thuillez},
  journal={Circulation},
  year={2000},
  volume={102 5},
  pages={491-3}
}
BACKGROUND The relative efficacy of endothelin-A (ET(A)) receptor blockade versus combined ET(A)-ET(B) receptor blockade in chronic heart failure (CHF) is still largely unknown. METHODS AND RESULTS We compared, in a rat model of CHF (coronary ligation), the hemodynamic and structural effects of 1 month of treatment with the ET(A) antagonist ABT-627 (5 mg x kg(-1) x d(-1)), the ET(B) antagonist A-192621 (30 mg x kg(-1) x d(-1)) or a combination of the 2 drugs. Doses were chosen for their… CONTINUE READING