Selective elimination of I(K,slow1) in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit.

@article{Li2004SelectiveEO,
  title={Selective elimination of I(K,slow1) in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit.},
  author={Huilin Li and Weinong Guo and Kathryn A. Yamada and Jeanne M Nerbonne},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 1},
  pages={
          H319-28
        }
}
Although previous studies have revealed a role for the voltage-gated K+ channel alpha-subunit Kv1.5 (KCNA5) in the generation of the 4-aminopyridine (4-AP)-sensitive component of delayed rectification in mouse ventricles (IK,slow1), the phenotypic consequences of manipulating IK,slow1 expression in vivo in different (mouse) models are distinct. In these experiments, point mutations were introduced in the pore region of Kv1.5 to change the tryptophan (W) at position 461 to phenylalanine (F) to… CONTINUE READING

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