Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation.

@article{Luster1988SelectiveEO,
  title={Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation.},
  author={Michael I. Luster and Dori R. Germolec and George C. Clark and Georg Wiegand and G J Rosenthal},
  journal={Journal of immunology},
  year={1988},
  volume={140 3},
  pages={928-35}
}
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the corticosteroid dexamethasone have potent effects on lymphocyte function, although the effects of the former have not been well characterized. In the present studies murine B cell maturation was used as a model system to examine and compare the effects of TCDD and dexamethasone on cell function. Immunosuppression by TCDD and dexamethasone is mediated by binding to specific intracellular R referred to as the Ah and… CONTINUE READING

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