Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats.

@article{Feng2001SelectiveEO,
  title={Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats.},
  author={M. G. Feng and S. A. Dukacz and R. Kline},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={281 5},
  pages={
          R1420-5
        }
}
  • M. G. Feng, S. A. Dukacz, R. Kline
  • Published 2001
  • Chemistry, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • The present study assessed the short- and long-term effect of tempol, a membrane-permeable mimetic of superoxide dismutase, on renal medullary hemodynamics in spontaneously hypertensive rats (SHR). Tempol was given in the drinking water (1 mM) for 4 days or 7 wk (4-11 wk of age), and medullary blood flow (MBF) was measured over a wide range of renal arterial pressure by means of laser-Doppler flowmetry in anesthetized rats. In addition, the response of the medullary circulation to angiotensin… CONTINUE READING
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