Selective effect of androgens on LH and FSH release in anterior pituitary cells in culture.

@article{Drouin1976SelectiveEO,
  title={Selective effect of androgens on LH and FSH release in anterior pituitary cells in culture.},
  author={Jacques Drouin and Fernand Labrie},
  journal={Endocrinology},
  year={1976},
  volume={98 6},
  pages={1528-34}
}
A possible direct effect of androgens at the pituitary level on gonadotropin release was studied using rat anterior pituitary cells in primary culture. The preincubation of cells with 3 X 10(-9)M testosterone (T) for 40 h increased the concentration of luteinizing hormone-releasing hormone (LHRH) required for half-maximal stimulation (ED50) of LH release from 3 X 10(-10)M to 1 X 10(-9)M. In the same experiment, the LHRH ED50 for FSH release (3 X 10(-10)M) was not affected by preincubation with… CONTINUE READING
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