Selective dye and ionic permeability of gap junction channels formed by connexin45.

  title={Selective dye and ionic permeability of gap junction channels formed by connexin45.},
  author={Richard D. Veenstra and Huanguang Wang and Eric C Beyer and Peter R. Brink},
  journal={Circulation research},
  volume={75 3},
Gap junctions are thought to mediate the direct intercellular coupling of adjacent cells by the gating of an aqueous pore permeable to ions and molecules of up to 1 kD or 8 to 14 A in diameter. We performed ion-substitution and dye-transfer experiments to determine the relative Cl-/K+ conductance and dye permeability of anionic fluorescein derivatives in chick connexin45 (Cx45) channels. We demonstrate that Cx45 forms a 26 +/- 6-picosiemen (pS) channel with a maximum detectable Cl- permeability… CONTINUE READING
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