Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle.

@article{Deruisseau2005SelectiveDO,
  title={Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle.},
  author={Keith C Deruisseau and Andreas N. Kavazis and Scott K. Powers},
  journal={Experimental gerontology},
  year={2005},
  volume={40 6},
  pages={526-31}
}
Aging-related alterations of the ubiquitin proteasome pathway (UPP) have been reported in locomotor skeletal muscle. Specifically, declines in proteasome activity have been observed in the soleus of senescent animals compared to the soleus of young controls. However, the influence of aging on the mRNA levels of key components within the ubiquitin conjugation cascade (UCC) remains unknown. We hypothesized that aged soleus muscle would exhibit downregulated expression of select UCC mRNA and… CONTINUE READING

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