Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects.

@article{Basu2007SelectiveDO,
  title={Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects.},
  author={Rita Basu and Utpal B. Pajvani and Robert A. Rizza and Phillip E Scherer},
  journal={Diabetes},
  year={2007},
  volume={56 8},
  pages={2174-7}
}
OBJECTIVE Adiponectin is an adipocyte-specific secretory protein found in circulation in several different forms and is present at significantly lower levels in the plasma of diabetic patients compared with that of insulin-sensitive individuals. We wanted to test whether insulin per se is a contributing factor toward lower plasma adiponectin concentrations and, if so, whether the splanchnic bed contributes to this phenomenon. RESEARCH DESIGN AND METHODS We sampled femoral artery and hepatic… CONTINUE READING

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