Selective down regulation of vascular beta 1 adrenergic receptors after prolonged isoproterenol infusion.

Abstract

Prolonged isoproterenol infusion (400 micrograms/kg/h for 4 days) in rats was previously shown to produce a reduction in the sensitivity of both cardiac and vascular beta-adrenergic receptors without affecting responsiveness to alpha 1 agonists or phosphodiesterase inhibitors in either vascular or cardiac muscle. The present study was designed to determine… (More)

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@article{Cohen1987SelectiveDR, title={Selective down regulation of vascular beta 1 adrenergic receptors after prolonged isoproterenol infusion.}, author={Marlene L. Cohen and Kathryn W Schenck}, journal={Journal of cardiovascular pharmacology}, year={1987}, volume={10 3}, pages={365-8} }