Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy.

@article{Hazell2001SelectiveDO,
  title={Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy.},
  author={Alan S. Hazell and Karanam Venkateswara Rao and Niels Christian Danbolt and David V. Pow and Roger F. Butterworth},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 3},
  pages={560-8}
}
Although earlier studies on thiamine deficiency have reported increases in extracellular glutamate concentration in the thalamus, a vulnerable region of the brain in this disorder, the mechanism by which this occurs has remained unresolved. Treatment with pyrithiamine, a central thiamine antagonist, resulted in a 71 and 55% decrease in protein levels of the astrocyte glutamate transporters GLT-1 and GLAST, respectively, by immunoblotting in the medial thalamus of day 14 symptomatic rats at loss… CONTINUE READING

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