Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition

@article{Mansbach1998SelectiveDD,
  title={Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition},
  author={Robert S. Mansbach and Elizabeth W. Brooks and Mark A. Sanner and Stevin H. Zorn},
  journal={Psychopharmacology},
  year={1998},
  volume={135},
  pages={194-200}
}
Abstract Recent evidence suggests that the dopamine D4 receptor may play a role in schizophrenia, and that the atypical properties of the antipsychotic clozapine may be attributable in part to its antagonistic actions at this receptor. In the present study, clozapine and three other compounds having D4 dopamine receptor antagonist properties were examined for their effectiveness in reducing losses in prepulse inhibition (PPI) induced in rats by the dopamine receptor agonist apomorphine… 

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