Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat

  title={Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat},
  author={Marie L. Woolley and Kerry A. Waters and Charles A. Reavill and Sharlene Bull and Laurent P. Lacroix and Abbe Martyn and Daniel M. Hutcheson and Enzo Valerio and Simon T. Bate and Declan Jones and Lee A. Dawson},
  journal={Behavioural Pharmacology},
Current therapies for attention deficit hyperactivity disorder comprise psychostimulants, which block the dopamine transporter and/or stimulate the release of dopamine, leading to a global elevation in extrasynaptic dopamine. These drugs are, however, associated with a series of unwanted side effects such as insomnia, anorexia, headache, stomach problems and potential drug abuse. Recent evidence suggests that the dopamine D4 receptor may represent a selective dopamine target that could mediate… 
Enhancement of gamma activity after selective activation of dopamine D4 receptors in freely moving rats and in a neurodevelopmental model of schizophrenia
The involvement of D4R in cortical gamma oscillations in vivo is demonstrated and this receptor is identified as potential target for pharmacological treatment of cognitive deficits.
Dopamine D4 receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia
D4 receptor agonism has a beneficial effect on novel object recognition in sub-chronic PCP-treated rats and augments the cognitive enhancing efficacy of an atypical antipsychotic drug that lacks affinity for the D4 receptor, lurasidone.
The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures.
Although dopamine D(3) receptor antagonists have been shown to enhance frontocortical cholinergic transmission and improve cognitive performance in rodents, data are limited and their effects have
The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task
Investigation of the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically found that D4 may contribute in some ways to decision making under this task.
Dopamine, cognitive function, and gamma oscillations: role of D4 receptors
The current state of knowledge of D4R functions in the PFC and hippocampus, two major brain areas implicated in SCZ, is reviewed, with special emphasis given to studies focusing on the potential role of D 4Rs in modulating GABAergic transmission and to an emerging concept of a close synergistic relationship between dopamine/D4R and neuregulin/ErbB4 signaling pathways.
Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors
The dopamine D4 receptor (DRD4) has a predominant expression in the prefrontal cortex (PFC), brain area strictly involved in the modulation of reward processes related to both food and drug consumption, and the presence of the 7R variant seems to increase the susceptibility of individuals to engage maladaptive eating patterns in response to negative environmental stimuli.


A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
It is suggested that clozapine's beneficial effects in schizophrenia may be achieved, in part, through D4-mediated GABA modulation, possibly implicating disinhibition of excitatory transmission in intrinsic cortical, thalamocortical and extrapyramidal pathways.
Chronic lithium attenuates dopamine D1-receptor mediated increases in acetylcholine release in rat frontal cortex
While lithium does not influence normal, arousal-related increases in cortical acetylcholine release, this ion selectively attenuates dopamine mediated increases and/or abnormally large increase, which in the present circumstances were pharmacologically induced.
Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine
It was shown that, consistent with its cortical procholinergic and catecholamine-enhancing profile, atomoxetine significantly ameliorated performance in the object recognition test and the radial arm-maze test, and was dependent upon norepinephrine α-1 and/or dopamine D1 receptor activation.
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
Oral methylphenidate is very effective in blocking dopamine transporters, and at the weight-adjusted doses used therapeutically (0.3 to 0.6 mg/kg), it is likely to occupy more than 50% of the dopamineTransporter.
A-412997 is a selective dopamine D4 receptor agonist in rats