Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat

@article{Woolley2008SelectiveDD,
  title={Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat},
  author={Marie L. Woolley and Kerry A. Waters and Charles A. Reavill and Sharlene Bull and Laurent P. Lacroix and Abbe Martyn and Daniel M. Hutcheson and Enzo Valerio and Simon T. Bate and Declan Jones and Lee A. Dawson},
  journal={Behavioural Pharmacology},
  year={2008},
  volume={19},
  pages={765-776}
}
Current therapies for attention deficit hyperactivity disorder comprise psychostimulants, which block the dopamine transporter and/or stimulate the release of dopamine, leading to a global elevation in extrasynaptic dopamine. These drugs are, however, associated with a series of unwanted side effects such as insomnia, anorexia, headache, stomach problems and potential drug abuse. Recent evidence suggests that the dopamine D4 receptor may represent a selective dopamine target that could mediate… Expand
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The novel dopamine D4 receptor agonist (PD 168,077 maleate): Doses with different effects on locomotor activity are without effect in classical conditioning
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No evidence is found that the D( 4) receptor has any likely effect on associative learning or its disorder, and D(4)-mediated hyperactivity was dissociable from cognitive effects. Expand
A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats
TLDR
A role for the dopamine D4 receptor subtype in cognition is supported in cognition by the potential cognitive enhancing properties of A-412997 in rat models of ADHD and short-term memory and in comparison with the less selective dopamine D 4 receptor agonists PD168077 and CP226269. Expand
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
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It is suggested that clozapine's beneficial effects in schizophrenia may be achieved, in part, through D4-mediated GABA modulation, possibly implicating disinhibition of excitatory transmission in intrinsic cortical, thalamocortical and extrapyramidal pathways. Expand
RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice
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The hypothesis that stimulation of D4R can enhance novelty seeking in mice and that this effect may be dependent on subtle genetic differences is supported. Expand
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A potential role of dopamine D4 receptors in memory consolidation is suggested, which would be similar to the D1 and D2 receptors and probably opposite to that of the D3 receptors. Expand
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Methylphenidate Preferentially Increases Catecholamine Neurotransmission within the Prefrontal Cortex at Low Doses that Enhance Cognitive Function
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At low doses that improve PFC-dependent cognitive function and that are devoid of locomotor-activating effects, MPH substantially increases NE and DA efflux within the PFC. Expand
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