Selective displacement chromatography in multimodal cation exchange systems.

@article{Sheth2011SelectiveDC,
  title={Selective displacement chromatography in multimodal cation exchange systems.},
  author={Rahul D Sheth and Christopher J. Morrison and Steven M. Cramer},
  journal={Journal of chromatography. A},
  year={2011},
  volume={1218 51},
  pages={9250-9}
}
A library of displacer analogues with varying degrees of electrostatic, hydrophobic and hydrogen bonding moieties was evaluated for their ability to enhance the selectivity of multimodal (MM) chromatography under high loading conditions. The library was screened for displacement of model proteins using a robotic liquid handling system and selective batch separations were achieved for proteins that were inseparable with linear gradient chromatography. Trends in protein displacement were… CONTINUE READING