Selective depression of synaptic transmission by tetanus toxin: a comparative study on hippocampal and neostriatal slices.

@article{Calabresi1989SelectiveDO,
  title={Selective depression of synaptic transmission by tetanus toxin: a comparative study on hippocampal and neostriatal slices.},
  author={Paolo Calabresi and Maura Benedetti and Nicola Biagio Mercuri and Giorgio Bernardi},
  journal={Neuroscience},
  year={1989},
  volume={30 3},
  pages={663-70}
}
Tetanus toxin reduces the release of neurotransmitters in several brain areas. We have studied the effects of this toxin on the intrinsic and synaptic activity of CA1 hippocampal neurons and of neostriatal cells in the rat by utilizing intracellular and extracellular recordings from slice preparations. Tetanus toxin (10 micrograms/ml) applied by bath produced an increase of the field potentials evoked by the orthodromic stimulation of the CA1 region coupled with the disappearance of the… CONTINUE READING

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