Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

@article{Revenko2011SelectiveDO,
  title={Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.},
  author={Alexey S Revenko and Dacao Gao and Jeff R. Crosby and Gourab Bhattacharjee and Chenguang Zhao and Chris Tam May and David Gailani and Brett P. Monia and A Robert Macleod},
  journal={Blood},
  year={2011},
  volume={118 19},
  pages={
          5302-11
        }
}
Recent studies indicate that the plasma contact system plays an important role in thrombosis, despite being dispensable for hemostasis. For example, mice deficient in coagulation factor XII (fXII) are protected from arterial thrombosis and cerebral ischemia-reperfusion injury. We demonstrate that selective reduction of prekallikrein (PKK), another member of the contact system, using antisense oligonucleotide (ASO) technology results in an antithrombotic phenotype in mice. The effects of PKK… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Factor XI and the contact system. The Online Metabolic and Molecular Basis of Inherited Disease

D Gailani, T. Renne, J. Emsley
  • 2010

Dual role of collagen in factor XII-dependent thrombus formation

PE van der Meijden, IC Munnix, +7 authors JW. Heemskerk
  • 2009