Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death.

Abstract

The hepatocellular glutathione content is partitioned into a cytosolic pool, which accounts for about 85% of the cellular glutathione content, and a mitochondrial pool, which accounts for about 15% of the cellular glutathione content. Previous studies indicated that the mitochondrial glutathione pool may play a critical role in cytoprotection against… (More)

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@article{Shan1993SelectiveDO, title={Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death.}, author={X. Shan and D. P. Jones and Muhammad Zaffar Hashmi and Marco Anders}, journal={Chemical research in toxicology}, year={1993}, volume={6 1}, pages={75-81} }