Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation.

@article{Champlin1990SelectiveDO,
  title={Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation.},
  author={Richard E. Champlin and Wildenskov Ho and James L. Gajewski and Stephen A. Feig and Michelle Burnison and Glenn P. Holley and Penny Greenberg and Ketty Lee and Irene Schmid and Janis V. Giorgi},
  journal={Blood},
  year={1990},
  volume={76 2},
  pages={
          418-23
        }
}
The effects of selectively depleting CD8+ cells from donor bone marrow were assessed in 36 patients receiving transplantation from an HLA-identical sibling as treatment for leukemia. Donor bone marrow underwent ex vivo treatment using anti-Leu-2 monoclonal antibody and complement. Patients received cyclosporine post-transplant for 6 months. Thirty-three patients had initial engraftment. Three failed to have hematologic recovery, and one patient with initial engraftment had late graft failure… CONTINUE READING

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