Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat

@article{Johansen1984SelectiveDD,
  title={Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat},
  author={Flemming Fryd Johansen and Martin Balslev J\orgensen and Dag K. J. Ekstr{\"o}m von Lubitz and Nils Henrik Diemer},
  journal={Brain Research},
  year={1984},
  volume={291},
  pages={373-377}
}
In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed. 

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