Selective dehybridization of DNA-Au nanoconjugates using laser irradiation.

@article{Asanuma2013SelectiveDO,
  title={Selective dehybridization of DNA-Au nanoconjugates using laser irradiation.},
  author={Hidehiko Asanuma and Zhifeng Jiang and Katsuyoshi Ikeda and Kohei Uosaki and Hua-Zhong Yu},
  journal={Physical chemistry chemical physics : PCCP},
  year={2013},
  volume={15 38},
  pages={
          15995-6000
        }
}
Plasmonic heating to trigger release of oligonucleotides from nanoconjugates is potentially useful for therapeutic purposes and designed assembly of DNA nanostructures. In the past, great controllability has been achieved by introducing distinctive absorption nanoparticle centers, where the anchoring bond (e.g., sulfur-gold bond) has been selectively broken. Instead of releasing the surface-bound duplex DNA via breakage of the gold-sulphur anchor bond, selective and non-destructive… 
View on PubMed
rsc.org
7 Citations
Methods Citations
1

7 Citations

Citation Type

Citation Type

Understanding Resonant Light-Triggered DNA Release from Plasmonic Nanoparticles.
TLDR
It is found that the characteristics of nanoparticle-based DNA release vary profoundly from the same nanoparticle complex, depending on the type of laser excitation, which has very important implications in the development of NIR-triggered gene or drug delivery nanocomplexes.
Analysis of photothermal release of Oligonucleotides from hollow Gold nanospheres by surface enhanced raman scattering (SERS)
TLDR
It is shown that HGNs with resonances at 760 and 670 nm release significant amounts of ssDNA when excited via 785 and 640 nm lasers, respectively, when excited with a wavelength far from the LSPR of the particles, the ssDNA release is negligible.
Mechanistic Understanding of DNA Denaturation in Nanoscale Thermal Gradients Created by Femtosecond Excitation of Gold Nanoparticles.
TLDR
Molecular dynamics simulations mimicking the photothermal heat pulse around a AuNP provide mechanistic insight into the stochastic nature of dehybridization and demonstrate increased base pair separation near the AuNP surface during laser pulse heating when compared to steady-state heating.
Optical Processing of DNA-Programmed Nanoparticle Superlattices.
TLDR
The interplay of structure-directing forces at multiple length scales is investigated by utilizing optical processing to influence both nanoscale and microscale features of self-assembled, DNA-grafted nanoparticle films.
Global DNA Methylation in the Chestnut Blight Fungus Cryphonectria parasitica and Genome-Wide Changes in DNA Methylation Accompanied with Sectorization
TLDR
The present study revealed that a mutation in a signaling pathway component resulted in sectorization accompanied with changes in genome-wide DNA methylation, which suggests that this signal transduction pathway is important for epigenetic control of sectorization via regulation of genes involved inDNA methylation.
Long‐range surface plasmon enhanced Raman spectroscopy at highly damping platinum electrodes
Plasmon Enhanced Raman Scattering from Molecular Adsorbates on Atomically Defined Planar Metal Surfaces

References

SHOWING 1-10 OF 61 REFERENCES
Photothermal release of single-stranded DNA from the surface of gold nanoparticles through controlled denaturating and Au-S bond breaking.
TLDR
It is shown that photothermal release of DNA from gold nanoparticles either by thermolysis of the Au-S bonds used to anchor the oligonucleotides to the nanoparticle or by thermal denaturation are not mutually exclusive and can be controlled by adjusting laser power and ionic strength.
Light-induced release of DNA from plasmon-resonant nanoparticles: Towards light-controlled gene therapy
Plasmonic nanorods provide reversible control over nanostructure of self-assembled drug delivery materials.
TLDR
The incorporation of plasmonic hydrophobized gold nanorods (GNRs) permits reversible manipulation of nanostructure on-demand, by irradiation of the matrix using a near-infrared laser.
Ultrafast Photothermal Release of DNA from Gold Nanoparticles.
  • F. Thibaudau
  • Chemistry, Biology
    The journal of physical chemistry letters
  • 2012
TLDR
It is shown that dehybridization of oligonucleotide duplex anchored on a gold nanoparticle surface occurs during a single laser pulse, leading to the release of single-strand DNA in solution.
Selective release of multiple DNA oligonucleotides from gold nanorods.
TLDR
This proof of concept demonstrates that it can load and selectively release two different DNA oligonucleotides from two different gold nanorods, potentially a powerful method for multiple-drug delivery strategies.
Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods.
TLDR
Investigation of the light-triggered release of DNA from two types of nanoparticle substrates suggests that a nonthermal mechanism may play a role in plasmon resonant, light- triggered DNA release.
Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna
TLDR
Remote electronic control over the hybridization behaviour of DNA molecules is demonstrated by inductive coupling of a radio-frequency magnetic field to a metal nanocrystal covalently linked to DNA, thereby inducing denaturation while leaving surrounding molecules relatively unaffected.
Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA.
TLDR
An engineered gold nanoshell (NS)-based therapeutic oligonucleotide delivery vehicle, designed to release its cargo on demand upon illumination with a near-infrared (NIR) laser, is demonstrated.
Visualizing light-triggered release of molecules inside living cells.
TLDR
It is shown that intracellular light-triggered release can be performed on molecules that associate with the DNA in a DNA host-guest complex bound to nanoshells, and this highly controlled co-release of nonbiological molecules accompanying the oligonucleotides could have broad applications in the study of cellular processes and in the development of intrACEllular targeted therapies.
Optically responsive gold nanorod-polypeptide assemblies.
TLDR
The generation of gold nanorod-elastin-like polypeptide (ELP) nanoassemblies whose optical response can be manipulated based on exposure to near-infrared (NIR) light is reported.
...
1
2
3
4
5
...