Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.

@article{Shu2013SelectiveDO,
  title={Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.},
  author={Minfeng Shu and Brunella Taddeo and Weiran Zhang and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 18},
  pages={E1669-75}
}
Herpes simplex virus 1 (HSV-1) encodes an endoribonuclease that is responsible for the shutoff of host protein synthesis [virion host shutoff (VHS)-RNase]. The VHS-RNase released into cells during infection targets differentially four classes of mRNAs. Thus, (a) VHS-RNase degrades stable cellular mRNAs and α (immediate early) viral mRNAs; (b) it stabilizes host stress response mRNAs after deadenylation and subsequent cleavage near the adenylate-uridylate (AU)-rich elements; (c) it does not… CONTINUE READING
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