Selective decrease of serum immunoglobulin G1 as a marker of malignant transformation in colorectal tissue.

@article{Schauenstein1997SelectiveDO,
  title={Selective decrease of serum immunoglobulin G1 as a marker of malignant transformation in colorectal tissue.},
  author={E. Schauenstein and H. Rabl and W. Steinschifter and Christian Bernd Hirschmann and Willibald Estelberger and Konrad Schauenstein},
  journal={Cancer},
  year={1997},
  volume={79 8},
  pages={1482-6}
}
BACKGROUND Malignant diseases of various origins were previously shown to be associated with a characteristic and highly significant change in the serum pattern of immunoglobulin (Ig)G subclasses, comprised of a decrease in %IgG1 and an increase in %IgG2 relative to and independent of the absolute concentration of total IgG. The goal of the current study was to evaluate this phenomenon as an indirect marker in the primary diagnosis of colorectal carcinoma. METHODS Using affinity… CONTINUE READING