Selective d‐opioid receptor antagonist N,N(CH 3) 2 ‐Dmt‐Tic‐OH does not reduce ethanol intake in alcohol‐preferring AA rats

@article{Ingman2003SelectiveDR,
  title={Selective d‐opioid receptor antagonist N,N(CH 3) 2 ‐Dmt‐Tic‐OH does not reduce ethanol intake in alcohol‐preferring AA rats},
  author={K. Ingman and S. Salvadori and L. Lazarus and E. Korpi and A. Honkanen},
  journal={Addiction Biology},
  year={2003},
  volume={8}
}
We studied the effect of a novel δ‐opioid receptor antagonist N,N(CH 3) 2 Dmt‐Tic‐OH (Me 2 ‐Dmt‐Tic‐OH) on voluntary ethanol intake in an alcohol‐preferring AA (Alko, Alcohol) rat line using a 4‐hour limited access paradigm. Acute injections of Me 2 ‐Dmt‐Tic‐OH (10 and 30 mg/kg, i.p.) did not reduce 1‐hour or 4‐hour ethanol intake. Subtype non‐selective opioid receptor antagonist naltrexone [0.1 and 0.3 mg/kg, subcutaneously (s.c.)] significantly reduced 1‐hour ethanol drinking but had no… Expand
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