Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis.

@article{Kotsyfakis2007SelectiveCP,
  title={Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis.},
  author={Michail Kotsyfakis and Shahid Karim and John F. Andersen and Thomas N. Mather and Jose M. C. Ribeiro},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 40},
  pages={29256-63}
}
Ixodes scapularis is the main vector of Lyme disease in the eastern and central United States. Tick salivary secretion has been shown as important for both blood-meal completion and pathogen transmission. Here we report a duplication event of cystatin genes in its genome that results in a transcription-regulated boost of saliva inhibitory activity against a conserved and relatively limited number of vertebrate papain-like cysteine proteases during blood feeding. We further show that the… CONTINUE READING

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