Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells

@inproceedings{Strillacci2010SelectiveCS,
  title={Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells},
  author={Antonio Strillacci and Cristiana Griffoni and Giorgia Lazzarini and Maria Chiara Valerii and Serena Di Molfetta and Fernando Rizzello and Massimo Campieri and Mary Pat Moyer and Vittorio Tomasi and Enzo Spisni},
  booktitle={British Journal of Cancer},
  year={2010}
}
Background:Cyclooxygenase-2 (COX-2) overexpression is strongly associated with colorectal tumourigenesis. It has been demonstrated that the chronic use of non-steroidal anti-inflammatory drugs (COX inhibitors) partially protects patients from colorectal cancer (CRC) development and progression but induces severe cardiovascular side effects. New strategies for selective COX-2 blockade are required.Methods:We developed an improved technique, based on RNA interference (RNAi), to gain a selective… CONTINUE READING

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