Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation.

@article{Baatar2002SelectiveCB,
  title={Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation.},
  author={Dolgor Baatar and Michael K. Jones and Rama Pai and Hirofumi Kawanaka and Imre L. Szabo and Woo Sung Moon and Seigo Kitano and Andrzej S. Tarnawski},
  journal={The American journal of pathology},
  year={2002},
  volume={160 3},
  pages={963-72}
}
Nonsteroidal anti-inflammatory drugs, both nonselective and cyclooxygenase-2 (COX-2) selective, delay gastric ulcer healing. Whether they affect esophageal ulcer healing remains unexplored. We studied the effects of the COX-2 selective inhibitor, celecoxib, on esophageal ulcer healing as well as on the cellular and molecular events involved in the healing process. Esophageal ulcers were induced in rats by focal application of acetic acid. Rats with esophageal ulcers were treated… CONTINUE READING
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