Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis.

@article{Laschke2007SelectiveCI,
  title={Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis.},
  author={Matthias W Laschke and Antje Elitzsch and Claudia Scheuer and Brigitte Vollmar and Michael Dieter Menger},
  journal={Fertility and sterility},
  year={2007},
  volume={87 1},
  pages={163-71}
}
OBJECTIVE To investigate the effects of selective cyclo-oxygenase-2 (COX-2) inhibition on the angiogenesis and proliferation of endometrial grafts. DESIGN Intravital fluorescence microscopic study. SETTING Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany. ANIMALS Syrian golden hamsters. INTERVENTIONS Endometrial fragments were transplanted into dorsal skinfold chambers of Syrian golden hamsters. Animals were treated daily with the selective… CONTINUE READING

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