Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)- mediated T cell apoptosis


Intracellular proteases appear to be important mediators of apoptosis. Substrates cleaved by proteases during apoptosis include nuclear autoantigens targeted in systemic autoimmune diseases. Using human autoantibodies as probes, we demonstrate here that T cell apoptosis mediated by CD95 (Fas/APO-1) is associated with substantial cleavage of a subset of… (More)


5 Figures and Tables

Slides referencing similar topics