Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.

@article{Bischof2001SelectiveCO,
  title={Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.},
  author={Oliver Bischof and Sanjeev Galande and Farzin Farzaneh and Terumi Kohwi-Shigematsu and Judith Campisi},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 15},
  pages={12068-75}
}
Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability. BLM, the protein defective in BS, is a RECQ-like helicase that is presumed to function in mammalian DNA replication, recombination, or repair. We show here that BLM, but not the related RECQ-like helicase WRN, is rapidly cleaved in cells undergoing apoptosis. BLM was cleaved to 47- and 110-kDa major fragments, with kinetics similar to the apoptotic cleavage of poly(A)DP… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…