Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

@article{Feldman1993SelectiveCI,
  title={Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.},
  author={Arthur M Feldman and Ellen O. Weinberg and Patricio E. Ray and Beverly H. Lorell},
  journal={Circulation research},
  year={1993},
  volume={73 1},
  pages={184-92}
}
Left ventricular hypertrophy (LVH) is associated with reinduction of the fetal program of gene expression. It is unclear whether this pattern of cardiac gene expression changes with the development of left ventricular decompensation and failure. To answer these questions, we quantified steady-state levels of mRNA by the polymerase chain reaction in the left ventricular myocardium of rats 8 and 20 weeks after ascending aortic banding. Clinical and hemodynamic assessment identified two distinct… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 136 extracted citations

Similar Papers

Loading similar papers…