Selective cell targeting with light-absorbing microparticles and nanoparticles.

@article{Pitsillides2003SelectiveCT,
  title={Selective cell targeting with light-absorbing microparticles and nanoparticles.},
  author={Costas Pitsillides and Edwin K Joe and Xunbin Wei and Richard R. Anderson and Charles P. Lin},
  journal={Biophysical journal},
  year={2003},
  volume={84 6},
  pages={4023-32}
}
We describe a new method for selective cell targeting based on the use of light-absorbing microparticles and nanoparticles that are heated by short laser pulses to create highly localized cell damage. The method is closely related to chromophore-assisted laser inactivation and photodynamic therapy, but is driven solely by light absorption, without the need for photochemical intermediates (particularly singlet oxygen). The mechanism of light-particle interaction was investigated by nanosecond… CONTINUE READING

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