Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine.

@article{Sato2015SelectiveCE,
  title={Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine.},
  author={Kazuhide Sato and Takahito Nakajima and Peter L. Choyke and Hisataka Kobayashi},
  journal={RSC advances},
  year={2015},
  volume={5 32},
  pages={25105-25114}
}
Cell cultures and tissues often contain cellular subpopulations that potentially interfere with or contaminate other cells of interest. However, it is difficult to eliminate unwanted cells without damaging the very cell population one is seeking to protect, especially established tissue. Here, we report a method of eliminating a specific subpopulation of cells from a mixed 2D or 3D cell culture in vitro and a mixed-population in vivo tumor model by using antibody-photosensitizer conjugates (APC… CONTINUE READING