Selective cell death of hyperploid neurons in Alzheimer's disease.

@article{Arendt2010SelectiveCD,
  title={Selective cell death of hyperploid neurons in Alzheimer's disease.},
  author={Thomas Arendt and Martina K. Br{\"u}ckner and Birgit Mosch and Andreas L{\"o}sche},
  journal={The American journal of pathology},
  year={2010},
  volume={177 1},
  pages={
          15-20
        }
}
Aneuploidy, an abnormal number of copies of a genomic region, might be a significant source for neuronal complexity, intercellular diversity, and evolution. Genomic instability associated with aneuploidy, however, can also lead to developmental abnormalities and decreased cellular fitness. Here we show that neurons with a more-than-diploid content of DNA are increased in preclinical stages of Alzheimer's disease (AD) and are selectively affected by cell death during progression of the disease… CONTINUE READING
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Cell Death of Hyperploid Neurons

  • YB Yurov, SG Vorsanova, IY Iourov, IA Demidova, AK Beresheva
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