Selective catalytic behavior of a phosphine-tagged metal-organic framework organocatalyst.


Steric hindrance by a metal-organic framework (MOF) is shown to influence the outcome of a catalytic reaction by controlling the orientation of its intermediates. This is demonstrated using an organocatalyst, phosphine MOF LSK-3, which is evaluated with the aid of molecular modeling and NMR spectroscopy techniques. This report is the first application of phosphine MOFs in organocatalysis and explores the potential of a framework steric hindrance to impose selectivity on a catalytic reaction. These findings expand the opportunities for control and design of the active site in the pocket of heterogeneous catalysts.

DOI: 10.1002/chem.201404498

Cite this paper

@article{Xu2014SelectiveCB, title={Selective catalytic behavior of a phosphine-tagged metal-organic framework organocatalyst.}, author={Xiaoying Xu and Stephan M Rummelt and Flavien L Morel and Marco Ranocchiari and Jeroen A van Bokhoven}, journal={Chemistry}, year={2014}, volume={20 47}, pages={15467-72} }