Selective breeding for increased cholinergic function: Increased serotonergic sensitivity

@article{Wallis1988SelectiveBF,
  title={Selective breeding for increased cholinergic function: Increased serotonergic sensitivity},
  author={Elisabeth Wallis and David H. Overstreet and Ann D. Crocker},
  journal={Pharmacology Biochemistry and Behavior},
  year={1988},
  volume={31},
  pages={345-350}
}
The effects of the serotonergic antagonist cyproheptadine and the agonist 1(m-chlorophenyl) piperazine (mCPP) on core body temperature, locomotor activity and operant responding for a water reward were determined in two lines of Sprague-Dawley rats selectively bred for differences in sensitivity to the anticholinesterase, diisopropyl fluorophosphate (DFP). Both cyproheptadine and mCPP induced a dose-dependent hypothermia that was significantly greater in the line of rat more sensitive to DFP… CONTINUE READING

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