Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method.

@article{Kakee1997SelectiveBT,
  title={Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method.},
  author={A Kakee and Tetsuya Terasaki and Yuichi Sugiyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 3},
  pages={1018-25}
}
Efflux transport of para-aminohippuric acid (PAH) across the blood-brain barrier (BBB) has been demonstrated by use of the brain efflux index (BEI) method. PAH was eliminated from the ipsilateral cerebrum extensively with an apparent efflux rate constant of 0.0587 (min-1) after microinjection into a cerebral cortex region termed Par2. This efflux transport showed a saturation with the Michaelis constant of approximately 400 microM. No more than 3% dose of PAH and carboxyl-inulin, used as a… CONTINUE READING
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