Selective blocking effects of tropisetron and atropine on recombinant glycine receptors.

@article{Maksay1999SelectiveBE,
  title={Selective blocking effects of tropisetron and atropine on recombinant glycine receptors.},
  author={G{\'a}bor Maksay and Bodo Laube and Heinrich Betz},
  journal={Journal of neurochemistry},
  year={1999},
  volume={73 2},
  pages={802-6}
}
Some serotonin 5-HT3 receptor ligands of tropeine structure have been recently shown to modulate ionophore function and binding of glycine receptors. This led us to study the effects of the tropeines tropisetron and atropine on recombinant human glycine receptors transiently expressed in Xenopus oocytes by using whole-cell voltage-clamp electrophysiology. Glycine currents were inhibited by atropine in an apparently competitive manner and with considerable selectivity of the tropeines for alpha2… CONTINUE READING