Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation.

  title={Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation.},
  author={Stefan Liebau and Christian Proepper and Tobias Maria Boeckers and Frank Lehmann-Horn and Alexander Storch and Stephan Grissmer and Oliver H Wittekindt},
  journal={Journal of neurochemistry},
  volume={99 2},
The modulation of cell proliferation in neural progenitor cells (NPCs) is believed to play a role in neuronal regeneration. Recent studies showed that K(+) channel activity influenced cell proliferation. Therefore, we examined NPCs for K(+) channels and tested whether NPC self renewing can be modulated by synthetic K(+) channel modulators. The whole-cell K(+) current was partly K(+) dependent and showed a cumulative inactivating component. Two tetra-ethyl-ammonium ion (TEA)-sensitive K… CONTINUE READING
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