Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

@article{Shoblock2010SelectiveBO,
  title={Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement},
  author={James R. Shoblock and Natalie Welty and Leah Aluisio and Ian C. Fraser and S. Timothy Motley and Kirsten L. Morton and J Palmer and Pascal Bonaventure and Nicholas I. Carruthers and Timothy W. Lovenberg and Jamin D. Boggs and Ruggero Galici},
  journal={Psychopharmacology},
  year={2010},
  volume={215},
  pages={191-203}
}
RationaleOrexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2 receptor has similar effects has not been determined. We have recently described the in vitro and in vivo effects of JNJ-10397049, a selective and brain penetrant orexin-2 receptor antagonist.ObjectiveThe goal of these studies was to evaluate whether systemic administration of JNJ-10397049 blocks the rewarding effects of ethanol and reverses… 

Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

TLDR
Results contribute to a growing body of evidence indicating that OX1 and OX2 receptor activity influences ethanol self-administration, although the effects may not be selective for ethanol consumption.

Influence of sigma-1 receptor modulators on ethanol-induced conditioned place preference in the extinction–reinstatement model

TLDR
It is concluded that sigma-1 receptor ligands can modulate the acquisition, expression, and reinstatement of conditioned reinforcing effects of ethanol with no reinforcing or aversive influence of their own.

Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.

TLDR
Findings implicate OX(2)R in the NAc in the nucleus accumbens in mediating the reinforcing effects of ethanol and suggest a potential therapeutic target for the treatment of ethanol-use disorders.

The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration

TLDR
It is demonstrated that orexin/hypocretin receptors in distinct brain regions regulate ethanol and sucrose mediated behaviors and almorexant decreased operant self-administration of both 20% ethanol and 5% sucrose.
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