Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

@article{Shoblock2010SelectiveBO,
  title={Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement},
  author={James R. Shoblock and Natalie Welty and Leah E Aluisio and Ian C. Fraser and S. Timothy Motley and Kirsten L Morton and James Palmer and Pascal Bonaventure and Nicholas I. Carruthers and Timothy W. Lovenberg and Jamin D. Boggs and Ruggero Galici},
  journal={Psychopharmacology},
  year={2010},
  volume={215},
  pages={191-203}
}
Orexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2 receptor has similar effects has not been determined. We have recently described the in vitro and in vivo effects of JNJ-10397049, a selective and brain penetrant orexin-2 receptor antagonist. The goal of these studies was to evaluate whether systemic administration of JNJ-10397049 blocks the rewarding effects of ethanol and reverses ethanol withdrawal… CONTINUE READING