Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

@inproceedings{Griebel2015SelectiveBO,
  title={Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents},
  author={G. E. Griebel and Philippe Pichat and Sandra Beesk{\'e} and Thibaud Leroy and Nicolas Redon and Agn{\`e}s Jacquet and Dominique Françon and Lionel Bert and Luc Even and Mati Lopez-Grancha and Tatiana Tolstykh and Fangxian Sun and Qunyan Yu and Scott Talmadge Brittain and Heike Arlt and Timothy He and Bailin Zhang and Dmitri Wiederschain and Thomas Bertrand and Jacques Houtmann and Alexey Rak and François Vall{\'e}e and Nadine Michot and Franck Aug{\'e} and V{\'e}ronique Menet and Olivier E. Bergis and Pascal George and Patrick Avenet and Vincent Mikol and Michel Didier and Johanna Escoubet},
  booktitle={Scientific reports},
  year={2015}
}
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent covalent MAGL inhibitor, SAR127303. The compound behaves as a selective and competitive inhibitor of mouse and human MAGL, which potently elevates hippocampal levels of 2-AG in mice. In vivo, SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. In addition, the drug alters learning performance in… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

Endocannabinoid mechanisms of pain modulation

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

An emotional buffer in the modulation of memory function

M. Morena, Campolongo, P. The endocannabinoid system
  • Neurobiol. Learn. Mem. 112, 30–43
  • 2013

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-alpha receptor activation in a genetic model of absence epilepsy

R Citraro
  • Neuropharmacology 69,
  • 2013

Antinociceptive activity without cannabimimetic side effects

Ignatowska-Jankowska, B. M. et al. In vivo characterization of the highly s KML29
  • Br. J. Pharmacol. 229, 591–601
  • 2013

Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats

Vilela, R L.
  • Epilepsy Res
  • 2013

Similar Papers

Loading similar papers…